Metastatic gastric cancer has a very poor prognosis and a low 5-year survial rate. lts incidence is particularly high in East Asia, highlighting a strong need for new therapeutic strategies
Current management relies mainly on surgery and systemic chemother apy, yet outcomes for metastatio disease remain limited. In addition, the heterogeneity of gastric cancer has hindered the establishment of robust biomarkers for targeted therapy
EMT iS a key process driving gastric cancer metastasis, and EPB41L5 shows elevated expression in patient groups associated with poor prognosis While EPB41L5-related signaling has been implicated in metastasis in other cancers, its function and clinical relevance in gastric cancer remain insufficiently defined-this study aims to address that gap
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